Stem Cells and Their Niches
Stem cell
growth and proliferation are
controlled by their specialized milieu, known
as the stem cell niche, through direct cell-cell interactions and chemical
signals emitted from the niche, according to
research on embryonic and adult stem cells. The stromal cell ensemble and the
factors produced by them, such as sticky signals, soluble factors, and matrix proteins, create the niche
.While we have a good understanding of how adult stem cells interact with their
surroundings, the essential components of the stem
cell niche are still unknown. Furthermore,
tissue-specific stem cells are anticipated to be found in particular niches
that must be characterized further in each tissue. To advance in situ
applications of in vitro
fertilization, progress in understanding
and building a stem cell niche will be required.
- Intestinal stem
cell niche
- The hair
follicle epidermal stem cell niche
- Hematopoietic
stem cell niche