Hematopoietic stem cell transplantation
Hematopoietic
stem cell transplantation (HSCT) is the intravenous infusion
of hematopoietic stem cells to restore blood cell production in individuals
with damaged or dysfunctional bone marrow or immune systems. This approach has
been utilized to treat a variety of malignant and nonmalignant
disorders with increasing frequency during the last
half-century. Cells for HSCT can be taken from the patient (autologous
transplant), a sibling or unrelated donor (allogeneic transplant), or an
identical twin (allogeneic transplant) (syngeneic transplant). Bone marrow,
peripheral blood, umbilical
cord blood, and foetal liver are all possible cell sources.
- Procurement of Stem Cells
- Manipulation of Stem Cell Grafts
- Preparative Regimens for HSCT
- Infusion of Stem Cells and Engraftment