About Conference
About Conference
The 4th Global Conference on Tissue Engineering and Regenerative Medicine, Stem Cell Research which is scheduled during August 25-26, 2022 virtually is focused on theme “Exploring innovation in Tissue Engineering and Regenerative Medicine” and to put forth the eminent research and development in eminent field of regenerative medicine and stem cells which the plays curial role in current and prospective technologies .The conference emphasizes on the vital role of stem cells and regenerative medicine in field of medicine and healthcare current trends in stem cell technology and future aspects of building the functional and infrastructural concept of stem cell therapy. Encompasses the spectrum of regenerative sciences from discovery to application and focuses on providing with understanding that spans traditional academic disciplines. It has innovative education experiences to produce the expert scientists needed to create the next generation of regenerative diagnostic and therapeutic solutions.
Regenerative medicine,
the foremost recent and emerging branch of bioscience, deals with functional
restoration of tissues or organs for the patient with severe injuries or
chronic disease. The spectacular progress within the field of vegetative
cell research has laid the inspiration for cell based therapies of disease
which cannot be cured by conventional medicines. The indefinite self-renewal
and potential to differentiate into other kinds of cells represent stem cells
as frontiers of regenerative medicine. The Transdifferentiating
potential of stem cells varies with source and consistent with that
regenerative applications also change. Advancements in gene editing and tissue
engineering technology have endorsed the ex vivo remodeling of stem cells grown
into 3D
organoids and tissue structures for personalized applications. This review
outlines the foremost recent advancement in transplantation and tissue
engineering technologies of ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs in
regenerative medicine. Additionally, it also discusses stem cells regenerative
application in wildlife conservation.
This conference plays a
world platform for biomedical companies, start-ups, clinical research
divisions, professionals, specialists, consultants, doctors, scholars and students
to border new relationship and strengthen the Knowledge. This can be an
excellent opportunity for all the delegates from Universities and Institutes to
interact with the highest grade world class Scientists. The actual participants
can confirm their participation through Registrations. To explore More
Regarding the Recent Research in somatic
cell its application attends Regentative
Medicine 2022.
Welcome Message
Welcome Message
With great delight and honor we invite the participants from all over the globe to take part in our annual flagship conference and explore your research and knowledge in our 4th Global Conference on Tissue Engineering and Regenerative Medicine, Stem Cell Research which is scheduled during August 25-26, 2022 virtually.
Sessions and Tracks
Track
1- Stem
Cells and Development
Stem
cells present in Human body are unspecialized cells. They have the power to
differentiate into any cell in an organism and to regenerate. Stem cells exist
both in embryos and adult cells. They are specialized into many stages. Each
stage reduces its developmental potency, where its produces unipotent stem cell
which can't differentiate into as many different types of cells as a pluripotent
cells.
- Adult stem cells
- Adult cells altered to have properties of embryonic stem
cells
- Perinatal stem cells
Related
Associations and Societies: Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Track
2- Tissue
Engineering
Tissue
engineering tries to use the self-healing characteristics of biological
tissues to regenerate and restore organ function. To do so, cells from
various origins, growth-inducing chemicals, and a biomaterial-support termed a scaffold
are utilized alone or in combination to reconstruct organs. However,
regenerating a functional tissue or organ has proven difficult. With recent
advancements in adult and embryonic stem cell technologies, the fantasy of
regenerating a full organ, or at least sections of it, appears to be closer
than ever.
- Bioartificial organs
- Biomimetics
- Long fiber generation
Related
Associations and Societies: California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine
Related
Conferences: Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium | Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings
Track
3- Organ
Regeneration
Organ
re-construction can be done in vitro in laboratories and made available on
demand, or in vivo using regenerative factors and a microenvironment
that allows organs to grow inside the body. The combination of stem cells with
tissue engineering has yielded significant advances, with the potential to
usher in a paradigm
change in regenerative medicine.
- Implantation
- Biopsy
- Cell isolation
- Scaffold
Related
Associations and Societies: California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine
Related
Conferences: Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium | Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings
Track
4- 3D
Bio-Printing and Organ Printing
Engineering,
manufacturing, art, education, and medicine are just a few of the fields where
three-dimensional (3D) printing is driving substantial changes. Biocompatible
materials, cells, and supporting components can now be 3D printed into
complex 3D functioning living tissues, thanks to recent advancements. To meet
the demand for transplantable tissues and organs, 3D bio printing is being used
in regenerative medicine. 3D bio
printing has more complexities than non-biological printing, such as
material selection, cell kinds, growth and differentiation variables, and
technical obstacles associated to living cell
sensitivities and tissue assembly. Engineering, biomaterials science, cell
biology, physics, and medicine must all work together to solve these problems.
Bio printing in 3D has already been used to create and test new drugs.
- 3D-bioprinted tissue models
- Inkjet based 3D
Bio printing
- Extrusion based
3D Bio printing
- Laser
assisted 3D Bio printing
- Stereolithographic
based 3D Bio printing
Related
Associations and Societies: California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Track
5- Embryonic
Stem Cells as a Powerful Tool
Human
embryonic stem cells (HESC) are pluripotent stem cell lines produced from
human blastocyst-stage embryos' inner cell mass (ICM). They are defined by
their culture's limitless ability for self-renewal. Furthermore, their ability
to generate virtually any cell type in vivo and in vitro demonstrates their
extensive developmental potential. HESC is tremendously essential in basic and
practical research because of these two characteristics. They could also be an
effective tool for understanding human development. By expressing
developmentally controlled genes and activating biological
pathways in the same way that they do in vivo, HESC can mimic embryogenesis.
They can also be used to investigate the impact of individual mutations on
specific developmental events, potentially allowing us to find crucial
components.
- Growth Factor–Induced Differentiation
- Ectoderm Differentiation
- Neuronal Differentiation
- Mesoderm Differentiation
Related
Associations and Societies: California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine
Related
Conferences: Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium | Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings
Track
6- Cancer
and stem cells
Cancer
Stem Cells (CSCs) are a small subpopulation of cells inside tumors with
abilities of self-renewal, differentiation, and tumorigenicity
while transplanted into an animal host. A variety of mobileular floor markers
including CD44, CD24, and CD133 are regularly used to pick out and enhance
CSCs. A regulatory community which includes microRNAs and Wnt/?-catenin,
Notch, and Hedgehog signaling pathways controls the CSC properties. The medical
relevance of CSCs has been bolstered with the aid of using rising evidence,
demonstrating that CSCs are resistant to traditional chemotherapy and radiation
remedy and that CSCs are very possibly to be the starting place of most cancers
metastasis. CSCs are believed to be an critical goal for novel anti-most
cancers drug discovery. Herein
we summarize the present day expertise of CSCs, with a focal point at the function
of miRNA and epithelial mesenchymal transition (EMT), and speak the medical
software of concentrated on CSCs for most cancers remedy.
- BMI-1
- Notch
- Sonic hedgehog and Wnt
Related
Associations and Societies: Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Track
7- Stem
cell therapy
Cell
therapy involves the introduction of cells directly into the body for the
purpose of healing. The therapeutic function propagates in single cell. For regenerative
medicine, the ultimate goal of cell
therapy is to establish a long-term transplant with the ability to carry
out the organ's functions. A practical example is a bone
marrow transplant, where HSCs are the therapeutic unit, which inserts the
bone marrow and regenerates the whole blood stream.
- Gene doping
- Human genetic engineering
- Treatment of genetic diseases
Related
Associations and Societies: California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine
Related
Conferences: Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium | Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings
Track
8- Stem
cells and tissue banks
Stem cell
banking or preservation is the extraction, processing and storage of stem
cells, which are stored and reserved for future prospective, when required. Stem
Cell has power to regenerate into any tissue or organ in your body. It is
due to this unique characteristic that they have the potential to treat over
life threatening conditions, and provide numerous benefits to the baby, its
siblings and the family.
- Tissue banking
- Tissue preservation
- Tissue storage
Related
Associations and Societies: Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Track
9- Biomaterials
and Scaffold Design
A fundamental component
of the regenerative endodontic process is the presence of a scaffold
for stem cells from the apical papilla to adhere to, multiply and
differentiate. The aim of this review is to provide an overview of the biomaterial
scaffolds that have been investigated to support stem cells from the apical
papilla in regenerative endodontic
therapy and to identify potential biomaterials for future research.
- Instructive
scaffolds
- Endodontic
therapy
- Blood-biomaterial interactions
Related
Associations and Societies: California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine
Related
Conferences: Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium | Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings
Track
10 - Regenerative
Medicine and Surgery
As the population ages,
there is an increasing need for organ and tissue replacement to cope with the
deterioration and disease of cardiovascular, gastrointestinal, kidney, and musculoskeletal
organs. Transplantation
of live and dead donor organs cannot currently meet this need. Regenerative
medicine is an interdisciplinary field that incorporates stem cell biology, immunology,
materials science, engineering, medicine, and surgery to develop solutions that
can enhance or replace the regenerative capacity of the body's own tissues.
With such a wide range of disciplines, it is important for different
stakeholders to understand where the overall picture of the process of
developing and clinically using regenerative medicine products fits. It also
discusses recent surgical applications in regenerative
medicine.
- Hand
transplantation
- Face
transplantation
- Lymphedema
- Preclinical modeling
Related
Associations and Societies: Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Track
11 - COVID-19
and Convalescent Plasma
The use of convalescent
plasma (CP) collected from the previously infected individuals to passively
transfer antibodies as to guard or treat human’s dates back almost 100 years.
Results from small cases series during the prior SARS and MERS coronavirus
outbreaks suggested that the Convalescent Plasma is safe and should confer
clinical benefits, including faster viral approval, particularly when
administered early within the disease course1. The overwhelming majority of
patients who get over COVID-19 illness develop circulating antibodies to varied
SARS-CoV-2 proteins 2-3 weeks following infection, which are detectable by ELISA
or other quantitative assays and sometimes correlate with the presence of
neutralizing antibodies. Donations can occur as frequently as weekly for
several months before antibody titers begin decreasing. Allowed donation
frequency varies between blood centers. Listed below are some sites for
referral of potential donors.
Related
Associations and Societies: California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine
Related
Conferences: Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium | Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings
Track
12 - Techniques
in stem cell research
Characterization of
stem cell cultures has two main purposes. Monitoring the integrity of the
cell's genome and tracking the expression of proteins associated with changes
in pluripotency of epigenetic profiles. Proteome analysis ensures that cells
express the factors necessary to maintain pluripotency. Confirmation of differentiation
status by analysis of important genetic and protein markers ensures correct
cell type identification and proliferation.
- Stem cell characterization
- Karyotyping
- Fluorescence in
situ hybridization (FISH)
- Comparative
genomic hybridization
Related
Associations and Societies: Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Track
13- Hematopoietic
stem cell transplantation
Hematopoietic
stem cell transplantation (HSCT) is the intravenous infusion of
hematopoietic stem cells to restore blood cell production in individuals with
damaged or dysfunctional bone marrow or immune systems. This approach has been
utilized to treat a variety of malignant and nonmalignant
disorders with increasing frequency during the last half-century. Cells for
HSCT can be taken from the patient (autologous transplant), a sibling or
unrelated donor (allogeneic transplant), or an identical twin (allogeneic
transplant) (syngeneic transplant). Bone marrow, peripheral blood, umbilical
cord blood, and foetal liver are all possible cell sources.
- Procurement of Stem Cells
- Manipulation of Stem Cell Grafts
- Preparative Regimens for HSCT
- Infusion of Stem Cells and Engraftment
Related
Associations and Societies: The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science |
Related
Conferences: Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit
Track
14- Regenerative
Pharmacology
Regenerative
pharmacology will have far higher development requirements. In fact, the
challenges associated with regenerative pharmacology, i.e., curative
therapeutics, will in many cases necessitate complex mixtures of compounds
[i.e., growth factors such as fibroblast
growth factor (FGF), epidermal growth factor (EGF), platelet-derived
growth factor, nerve growth factor (NGF), vascular endothelial
growth factor (VEGF), insulin-like growth factor (IGF), bone morphogenic
proteins (BMPs These chemicals have far greater molecular weights (usually
10,000 to >100,000 mol. wt.) than those created historically by the
pharmaceutical industry..
- Cell
mobilization
- Chemokines
- Genitourinary
regeneration
- Musculoskeletal
regeneration
Related
Associations and Societies: Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Track
15 - Regenerative
Medicine and Disease Therapeutics
Human
pluripotent stem cells (HPSCs) are useful model system for understanding
the genetic basis of human cardiovascular diseases. HPSCs are often firmly
genetically matched to patients with disease. Previously, only in unusual
substance was it viable to review primary tissues like heart muscle and blood
vessels obtained directly from living patients, and even in such circumstances,
the quantity of tissue was limited. HPSCs produce a replacement approach that
gives a unique opportunity to review human cells that are matched to the
patients of interest. Because they will be propagated into very large numbers
and differentiated into a spread of cell types that are relevant to
cardiovascular diseases—including cardio myocytes,
vascular endothelial and smooth muscle cells, and hepatocytes—HPSCs
can in theory provide a limitless source of fabric with which to dissect the
molecular support of the patient’s disease process within and beyond the
circulatory system.
Related
Associations and Societies: The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science |
Related
Conferences: Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit
Track
16 - Translational
Research in Stem Cell Assessments
Stem cell therapy
has immense potential to relieve human suffering and give solutions to medical
issues that are now unfulfilled. Stem cells must follow the same regulatory
procedure as drugs to reach the clinic. Investigator-initiated methods
frequently use stem cells as pharmaceuticals; therefore investigators must be
aware of these regulatory mechanisms from the beginning of the translational
process. Furthermore, because of the highly complicated nature of cells as
pharmaceuticals, the translational
pathway to development will necessitate specific considerations.
- Dose exploration
- Patient-specific
products
- Safety
monitoring and follow-up to mitigate risk to the patients
Related
Associations and Societies: Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science | The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Track
17 - Stem
Cells and Their Niches
Stem cell
growth and proliferation are
controlled by their specialized milieu, known
as the stem cell niche, through direct cell-cell interactions and chemical
signals emitted from the niche, according to research on embryonic and
adult stem cells. The stromal cell ensemble and the factors produced by them,
such as sticky signals, soluble factors, and
matrix proteins, create the niche .While we have a good understanding of how
adult stem cells interact with their surroundings, the essential components of
the stem
cell niche are still unknown. Furthermore, tissue-specific stem cells are
anticipated to be found in particular niches that must be characterized further
in each tissue. To advance in situ applications of in vitro
fertilization, progress in understanding and building a stem cell niche
will be required.
- Intestinal stem
cell niche
- The hair
follicle epidermal stem cell niche
- Hematopoietic stem cell niche
Related
Associations and Societies: The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science |
Related
Conferences: Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit
Track
18 - Multiplexed
genome regulation
Multiplexed modulation
of endogenous genes is vital for sophisticated gene therapy and cell
engineering. CRISPR–Cas12a
systems enable unique multiple-genomic-loci targeting by processing numerous
CRISPR RNAs (crRNAs) from a single transcript; however, their low efficiency is
preferred in vivo applications. Through structure-guided protein engineering,
we developed a hyper-efficient Lachnospiraceae
bacterium Cas12a variant, termed hyperCas12a, with its catalytically dead
version hyperdCas12a showing significantly enhanced efficacy for gene
activation, particularly at low concentrations of crRNA. We demonstrate that hyperdCas12a
has comparable off-target effects compared with the wild-type system and
exhibits enhanced activity for gene editing and repression. Delivery of the
hyperdCas12a activator and a single crRNA array simultaneously activating the
endogenous Oct4, Sox2 and Klf4 genes in the retina of post-natal mice alters
the differentiation of retinal progenitor cells. The hyperCas12a system offers
a versatile in vivo tool for a broad range of gene-modulation and gene-therapy
applications.
- CRISPR Csy4
- Multiplexing
metabolic engineering
- Gene editing
- CRISPRi
Related Associations and Societies: Australasian Society for Stem Cell Research | Korean Society for Stem Cell Research | The Japanese Society for Regenerative Medicine | California's Stem Cell Agency | New York Stated Stem Cell Science | The New York Stem Cell Foundation | Stem Cell Network | Brazilian Association of Cellular Therapy | Euro Stem Cell | German Stem Cell Network
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Track
19 - Stem
Cell Apoptosis & Signal Transduction
Apoptosis
is a type of customized cell demise which occurs in multicellular creatures.
When a cell is prompted to apoptosis, a few trademark cell morphological
changes follow which incorporate blebbing, cell shrinkage, atomic fracture, chromatin
buildup, chromosomal DNA discontinuity, and worldwide mRNA rot. Somewhat,
the self-restoration and populace of undeveloped cell is constrained by
apoptosis. Apoptosis keeps foundational microorganism number in balance between
the lost because of separation or apoptosis and the acquired because of the
multiplication.
- Fas-induced
Apoptosis
- TNF-induced Apoptosis
- TRAIL-induced
Apoptosis
Related
Associations and Societies: The
New York Stem Cell Foundation | Stem
Cell Network | Brazilian
Association of Cellular Therapy | Euro
Stem Cell | German
Stem Cell Network Australasian
Society for Stem Cell Research | Korean
Society for Stem Cell Research | The
Japanese Society for Regenerative Medicine | California's
Stem Cell Agency | New
York Stated Stem Cell Science |
Related
Conferences: Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit
Track
20 - Regulation
and ethics of stem cells
Stem cell research
offers great promise for understanding basic mechanisms of human development
and differentiation, as well as the hope for new treatments for diseases such
as diabetes, spinal cord injury, Parkinson’s
disease, and myocardial infarction. However, human stem cell (hSC) research
also raises sharp ethical and political controversies. The derivation of pluripotent
stem cell lines from oocytes
and embryos is fraught with disputes about the onset of human personhood. The
reprogramming of somatic cells to produce induced pluripotent stem cells avoids
the ethical problems specific to embryonic
stem cell research. In any hSC research, however, difficult dilemmas arise
regarding sensitive downstream research, consent to donate materials for hSC
research, early clinical trials of hSC therapies, and oversight of hSC
research. These ethical and policy issues need to be discussed along with
scientific challenges to ensure that stem cell research is carried out in an
ethically appropriate manner. This article provides a critical analysis of
these issues and how they are addressed in current policies.
Related Associations and Societies: Australasian Society for Stem Cell Research | Korean Society for Stem Cell Research | The Japanese Society for Regenerative Medicine | California's Stem Cell Agency | New York Stated Stem Cell Science | The New York Stem Cell Foundation | Stem Cell Network | Brazilian Association of Cellular Therapy | Euro Stem Cell | German Stem Cell Network
Related
Conferences: Stem
Cell Conference | Stem
Cell Conferences | Regenerative
Medicine Events | Tissue
Engineering Meetings | Tissue
Science Summit | Cancer
Workshops | Cell
Science Congress | Biomarkers
Symposium
Market Analysis
Market
Analysis
The field of regenerative medicine comprises of abundant strategies, which mainly includes the utilization of materials and de novo generated cells, also as various amalgamations therefore, to substitute the lost tissue, efficiently replacing it both anatomically and functionally, or to contribute to tissue restoration. The most objective of regenerative medicine is to propagate replacement tissue or organs for patients who have sustained an injury or have had a disease that permanently damaged their tissue. National Institutes of Health defines regenerative medicine as a process of making living, functional tissues to repair or replace tissue or organ function lost thanks to age, disease, damage, or congenital defects.
Regenerative Medicine Market Report Highlights
- The
therapeutics segment dominated the market in 2020 due to the high usage of
primary cell-based
therapies along with advances in stem cell and progenitor
cell therapies. The implementation of these therapies in dermatological,
musculoskeletal, and dental application results in the highest share of this
segment
- With
the rise in R&D and clinical trials of regenerative medicines, key players
are offering several consulting services leading to lucrative growth of the
services segment
- The
oncology
segment is estimated to account for the largest revenue share by 2027 owing to
the high prevalence of cancer indications, which drives the demand for better
solutions. The presence of a strong pipeline of regenerative
medicines for cancer treatment also supplements the segment
growth
- North
America dominated the market in 2020 and is projected to continue its dominance
over the forecast period. A significant number of universities and research
organizations investigating various stem cell-based approaches for regenerative
apposition in the U.S. propels the region's growth
- Asia Pacific is projected to witness the fastest CAGR over the forecast period due to the emergence of key players and rapid adoption of cell-based approaches in the healthcare