Tissue Engineering and Regenerative Medicine extends the heartiest welcome to proficient delegates, scientists, professors, students, young researchers, business executives, scholars, chemists and professionals across the globe to be a part of “Global Conference on Tissue Engineering and Regenerative Medicine” on March 25-26, 2019, to be held at Amsterdam, Netherlands. Keynote speech, exhibitions, oral and poster presentations outline the key attractions of the conference on the theme “ Innovate, Integrate & Motivate with Tissue Engineering and Regenerative Medicine”.
Allied Academies organizes Tissue Engineering and Regenerative Medicine 2019 conference along with 300+ Conferences across USA, Europe & Asia every year with support from 1000 more scientific societies and Publishes 400+ Open access journals which contain over 30000 eminent personalities as editorial board members.
We are pleased to invite you to join us at the tissue engineering and regenerative medicine conference 2019, where you will be sure to have a meaningful experience with scholars from around the world. All members of the organizing committee look forward to meeting you in Amsterdam, Netherlands.
Session 1. Tissue Engineering
Tissue engineering is an interdisciplinary course dealing with the building up of new Organs. It reveals us the truth that the nature can be imitated by the evaluation of tissue engineering. It substitutes the biological functions by replacing the replaced or damaged tissues by the combination of cells, organic materials and biochemical factors. It involves implantation, Restoration and regeneration of tissues. The main goal of tissue engineering is to develop the diseased or damaged tissues in a body or Cells attached to ECM (Extra Cellular Matrix).
- Animal models of tissue regeneration
- Intrinsic tissue regeneration
- Guided tissue regeneration
- Human tissue regeneration
- In silico tissue engineering
Session 2. Regenerative Medicine
As we grow older our body parts fail to function in a normal way. Our current Medical technology helps in regenerating the damaged body parts. Many species can regenerate by themselves. For example a Salomon can regrow its limbs, tails etc. whereas in human it is possible only for the liver to regenerate. Thus Regenerative Medicine promises the repair of body parts with their own living tissues by inculcating Scaffolds.
- Molecular fundamentals of regeneration
- Treatment models
- Recapitulating tissue and organ structure
Session 3. Scaffolds in Tissue Engineering
Scaffolds are Biomaterials coated with our body cells reproducing cartilages, kidneys and even complex Organs like heart and lungs. Scaffolds are a potential to change the way we live. The type of composition depends on Tissue but involves
- Structural protein- collagen, elastin
- Adhesive protein- fibronectin, laminin
- Proteoglycans including polysaccharides and glycosaminoglycans (GAGS)
Session 4. Biomaterials
Biologic Tissues consist of the cells, the extracellular matrix (made up of a complex of cell secretions immobilized in spaces continuous with cells), and the signaling systems, which are brought into play through differential activation of Genes or cascades of genes whose secreted or transcriptional products are responsible for cueing tissue building and differentiation. The principal components of scaffolds (into which the extracellular matrix is organized in actual tissues) are collagen Biopolymers, mainly in the form of fibers and fibrils. Other forms of polymer organization have also been used (gels, foams, and membranes) for engineering tissue substitutes. The various forms can be combined in the laboratory to create imitations of biopolymer organization in specific tissues. Scaffolds can be enriched with signaling molecules, which may be bound to them or infused into them.
- Cell seeding
- Cell encapsulation and micro encapsulation
- Cell sheets
Session 5. Acellular Prosthesis
The use in Animal models and in humans of complex allogeneic and xenogeneic tissues, depleted of their living cells is by freezing or other methods, has been shown to be immunologically acceptable without the use of Immunosuppressants. It is known from studies in experimental animals and humans that acellular allogeneic and tissues, many available through tissue banks, is becoming well established. Further, the growing xenogeneic implants have been accepted by their hosts. Acellular collagen matrices, in the form of foams with and without bone precursor minerals, have been used as vehicles for delivering a variety of Bone
- Morphogenetic proteins
- Prosthesis based breast reconstruction
- Acellular dermal matrices
- Soft tissue replacement
Scaffolds can be populated with adult-derived cells that are capable of undergoing subsequent differentiation after being cultivated in vitro. In this category are cells of the skin, cartilage, muscle, tendon, ligament, bone, adipose tissue, endothelium, and many others. Aside from skin, the foregoing cell types are harbored as stem cell populations in the marrow, in addition to those of the hematopoietic and immune systems, but the diversity of mesenchymal and possibly other cell types in the marrow still needs to be probed. Stimulating factors, the cytokines,which move some of the cells into the circulation, will be important for engineering Acellular Scaffolds. Other stem cells are available to Tissue Engineering, such as the satellite cells found in striated muscle and to some degree keratinocytes of the skin. Where host cells are available, an acellular scaffold, particularly one enhanced with signals and possessing the binding sites needed for cell attachment, can mobilize host cells that will populate the Prosthesis.
- Cancer stem cells
- Mesenchymal stem cells
- Stem cell therapy
- Hematopoietic stem cells
- Embryonic stem cells
- Tissue specific stem cells
- Induced pluripotent stem cells (IPSC)
- Amniotic stem cell
Session 7. Regenerative Treatment Models
The field of Regenerative Medicine encompasses numerous
strategies, including the use of materials and de novo generated cells, as well as various combinations
thereof, to take the place of missing tissue, effectively replacing it both
structurally and functionally, or to contribute to Tissue healing. The body's innate healing response
may also be leveraged to promote regeneration, although adult humans possess
limited regenerative capacity in comparison with lower vertebrates. This review
will first discuss regenerative medicine therapies that have reached the Market. Preclinical and early clinical
work to alter the physiological environment of the patient by the introduction
of materials, living cells, or growth factors either to replace lost tissue or
to enhance the body's innate healing and repair mechanisms will then be
reviewed. Strategies for improving the structural sophistication of Implantable Grafts and effectively using recently developed cell
sources will also be discussed.
- Tissue remodeling
- Apoptosis inhibition
- Cell differentiation
- 3D tissue printing
Session 8. Formation of 3D Printing of Biomaterials
The formation of a 3-dimensional structure of Biomaterials is known as the 3D printing. According to the number of dimensions in nano-scale, the Biomaterials are of three types- 3D (nano-particle), 2D (i.e. nano-fiber), and 1D (nano-sheet). 3D Bio Printing is the creation of various cell patterns by using printing techniques along with the layer-by-layer method to form tissue mimetic structures without any loss in cell function that can be further used in Tissue Engineering. Bio printing helps in the research of drugs and pills by printing tissues and Organs. It is also used for micro-devices and microarrays. The 3D printing materials market is expected to reach USD 1,409.5 Million by 2021 from USD 580.1 Million in 2017, at a CAGR of 22.60%.
- High-energy handling of biomaterials
- Electro Spinning and Allied Technologies
- In 3D Bio-printing
- Layer-by-layer: 1, 2 and 3D Nano Assembly
- Hierarchical Three Dimensional Structures
Session 9. Regenerative Medicine Market
There are strong pricing pressures
from public healthcare payers globally as Governments try to reduce budget
deficits. Regenerative Medicine could potentially save public
health bodies money by reducing the need for long-term care and reducing
associated disorders, with potential benefits for the world economy as a whole.
The global market for Tissue Engineering and regeneration products reached
$55.9 billion in 2010, is expected to reach $59.8 billion by 2011, and will
further grow to $89.7 billion by 2016 at a compounded annual growth rate (CAGR) of 8.4%. It grows
to $135 billion to 2024. The contribution of the European region was 43.3% of
the market in 2010, a value of $24.2 billion. The market is expected to reach
$25.5 billion by 2011 and will further grow to $36.1 billion by 2016 at a CAGR
of 7.2%. It grows to $65 billion to 2024.
Session 10. Bone Tissue Engineering
of musculoskeletal tissues, especially bone and ligament, is an emerging field.
In bone, innovation has focused on bone graft materials and the advancement of
biodegradable frameworks. Tissue designing methodologies has included cell and Gene
Session 11. 3D Bio-printing Techniques
The 3D Bio-printing uses techniques to combine the cells, growth factors and Biomaterials to reach the maximum imitation. It can print tissues, Organs to incorporate drugs and pills and even scaffolds. It has found a massive use in the field of Regenerative Medicine.
- Autonomous self-assembly
Session 12.Organ Engineering
The transplantation of a whole organ with new therapeutic means that may overcome the Drawbacks involved in the current Artificial Organs. It is an exciting Research Area that aims at Regenerative Alternatives to harvested tissues for organ transplantation with soft tissues. As a result of the medical and market potential, there is significant academic and corporate interest in this technology.
- Cellular Interactions
- Hybrid artificial organs
- Modeling of Organs
- Microbial Sterilization
- Microbial Decontamination
Session 13. Ethical and Legal Issues
As a field, Tissue Engineering has been defined for little more than a decade. Much still needs to be learned and developed to provide a firm scientific basis for Therapeutic Application. Up to date, much of the progress in this field has been related to the development of model systems, which have suggested a variety of approaches. Also, certain principles of cell biology and tissue development have been delineated. The field can draw heavily on the explosion of new knowledge from several interrelated well-established disciplines, and, in turn, may promote the coalescence of relatively new, related fields to achieve their potential. The rate of new understanding of complex living systems has been explosive in the past three decades. Tissue engineering can draw on the knowledge gained in the fields of cell biology, biochemistry, and molecular biology and apply it to the engineering of new tissues. Likewise, advances in Materials Science, chemical engineering, and Bioengineering allow the rational application of engineering principles to living systems. Yet another branch of related knowledge is the area of human therapy as applied by surgeons and physicians.
Session 14. Stem Cell Transplant
Stem Cell Transplantation is a system that is regularly suggested as a treatment choice for individuals with leukemia, different myeloma, and a few sorts of lymphoma. It might likewise be utilized to treat some hereditary sicknesses. In this process diseased bone marrow (the springy, greasy tissue found inside bigger bones) is treated with Chemotherapy as well as radiation Treatment and afterwards replaced with the stem cells.
Session 15. Embryonic Stem Cells
Embryonic Stem Cells can develop (i.e. separate) into all
subsidiaries of the three essential germ layers: ectoderm, endoderm and
mesoderm which make them Pluripotent. As such, they can form into each of the
more than 200 cell sorts of the grown-up body as long as they are indicated to
do as such. They are recognized by two particular properties: their
pluripotency, and their capacity to duplicate.
Advancements in gene editing and Tissue Engineering technology have endorsed the ex vivo remodeling of stem cells grown into 3D Organoids and tissue structures for personalized applications. This review outlines the most recent advancement in transplantation and tissue engineering technologies of ESCs, TSPSCs, MSCs, UCSCs, BMSCs, and iPSCs in Regenerative Medicine. Additionally, this review also discusses stem cells regenerative application in wildlife conservation.
- Wound healing
Session 17. Future Scope- Biomedical Technology
Biomedical Innovation guarantees numerous new advancements. Specialists are exploring different avenues regarding various treatment alternatives that utilize Tissue building. Tissue recovery will majorly affect twisted treatment, as patients get recovered tissue to fill in substantial injuries that would be difficult to recuperate in the typical mold. Scarring would be diminished, giving more noteworthy personal satisfaction to patients after calamitous damage. Remade veins could be utilized to enable patients with cardiovascular illness to give better heart to work and a full come back to typical exercises. Liver Tissue from patients could be developed in lab to give methods for testing the most effective pharmaceuticals for treatment, rather than the experimentation strategy being utilized on the patient himself. Later on, entire organs might be developed to give transplant new parts to patients with kidney or heart damage. Athletic wounds to ligament and bone could be repaired all the more quickly with Regrown Tissue from the patient's own body.
Regenerative Medicine Market Overview:
Regenerative medicines are used to repair, replace, and regenerate tissues and organs affected by injury, disease, or natural aging process. These medicines restore the functionality of cells & tissues and are used in several degenerative disorders such as dermatology, neurodegenerative diseases, cardiovascular, and orthopaedic applications. Stem Cells are capable of proliferation and differentiation, which increase their importance in this field. The global regenerative medicine market was valued at $5,444 million in 2016, and is estimated to reach $39,325 million by 2023, registering a CAGR of 32.2% from 2017 to 2023.
The factors driving the growth of this market include emergence of Stem cells technology, untapped potential of nanotechnology, and increase in prevalence of chronic diseases & trauma emergencies, advancement in monitoring devices and surgical technologies, rise in incidence of degenerative diseases, and shortage of Organs for transplantation. Increase in focus on stem cells and growth in R&D activities in emerging economies are expected to supplement the market growth. The developing nations are focused on technological advancements, which is expected to boost the market growth, globally. However, stringent government regulations, operational inefficiency, and high cost of treatment through regenerative medicine are estimated to hamper the growth of the market.
Type Segment Review
Based on product type, the market is segmented into cell therapy, gene therapy, tissue engineering, and small molecules & biologics. Moreover, among all the regenerative medicine products, the cell therapy segment has the most promising future due to its efficiency to restore the lost function of tissues and organs. In addition, the small molecules & biologics segment is expected to grow at the highest CAGR of 33.3% from 2017 to 2023, due to its potential to stimulate dormant or endogenous cells to regain their regenerative properties.
Material Segment Review
Based on material, the market is divided into synthetic material, biologically derived material, genetically engineered material, and pharmaceutical. The biologically derived material was the dominant segment in 2016, and is estimated to maintain this trend during the analysis period. The demand for genetically engineered material has increased due to their unique properties such as promotion of cellular interactions, increased proliferation, and differentiation of cells that facilitate self-assembly into directionally organized structures, and control the manipulation of cellular behaviour.
Key Geographical Segment
As per region, the regenerative medicine market is analyzed across North America, Europe, Asia-Pacific, and LAMEA. North America accounted for the largest market share in 2016, and is expected to retain its dominance throughout the forecast period.
Amsterdam, capital of the Netherlands! These days the city has a population of just over 790.000 inhabitants and is the largest city in the country. Amsterdam is located in the province ‘Noord-Holland’, situated in the west. It is one of the most popular destinations in Europe, receiving more than 4.5 million tourists annually.
Amsterdam has a great history. It is very unique for its large and untouched historic center. It has a rich architectural history, dominated by water. It is a meeting point for all different cultures around the world and has a welcoming attitude towards visitors. Well known for its museums, red light district, coffee shops but also the great variety of eating & drinking places and night life. It even claims to be the ‘Gay capital of Europe’. Therefore a lot of hotels and hostels can be found on different locations, value for money and ambience.It is a beautiful and romantic city with its antique houses, lovely bridges, famous canals and of course the list of world class attractions!